Janet Jackson diagnosed with Uterine fibroids is currently in a ward. These are tumors found in the uterus. The cause of uterine fibroids is unknown though there is evidence progestogen and estrogens aggravate the growth of tumors as in most cases they regress after menopause. However, this is not the case in Janet’s case as she is a 40-year-old woman a few years shy of menopause.
Etiology and Pathophysiology
The etiology of fibroids highlights a wide prospect of theories. Fibroids are usually made up of smooth muscle cells. Organs of the body like the stomach and the uterus are made of smooth muscles cells. It is why in women with fibroids, the endometrium looks normal under a microscope. In some instances however, an abnormality referred to as the glandular functionalis is the first clinical clue for doctors to examine a patient closely for submucosal fibroid (Tinelli et al., 2015). Janet has leiomyomas usually referred to as clonal, result from alterations of a single myoma cell. Estrogen promotes the growth of Leiomyomas but sometimes they may be triggered by low absence of estrogen. It is possible to have some scenario where ovarian and adrenal androgens are transformed to estrogen by aromatase activity in the myoma cells (Tinelli et al., 2015).